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What are vaccines, and how do they work?

Typically, vaccines are a medicine administered by injection – hence the terms ‘jabs’ and ‘shots’. 


They can also be taken orally, and newer forms include sprays (e.g. FluMist). 

 

UK and US health authorities describe their proposed health benefits and actions as follows:

 

  • Vaccines work by imitating an infection to engage the body’s natural defenses. 
  • Vaccines help the body learn how to defend itself from disease without the dangers of a full-blown infection. 


Source: CDC

Child holding mother's hand

The goal: immunity from disease

A small amount of the disease pathogen is introduced to your body. It is thought that your body then learns how to recognise the disease, and is therefore primed to overcome the infection itself when/if it is encountered.  


It is claimed that the pathogen in vaccines is rendered harmless by, for example: 


  • killing the pathogen;  
  • making the pathogen unable to grow or divide (attenuated vaccine); or  
  • using fragments of pathogens, which include the necessary antigens (rather than whole cells). 


Source: Edexcel Biology  


[Note: mRNA vaccines work differently from traditional vaccines. Learn more here.]


We are told that: 


  • It's much safer for your immune system to learn through vaccination than by catching the diseases and receiving treatment.  
  • Once your immune system knows how to fight a disease, it can often give you life-long protection. 


The NHS highlights the benefits not only for the individual, but for society at large:  


‘Having a vaccine also benefits your whole community through "herd immunity". 

If enough people are vaccinated, it's harder for the disease to spread to those people who cannot have vaccines. For example, people who are ill or have a weakened immune system.’ 


Source: NHS 

Glossary of terms

Immune system 

A large network of organs, white blood cells, proteins and chemicals. This protects you from germs and other invaders. Your immune system also helps your body heal from infections and injuries. 


Pathogen 

Any organism that causes disease – for example, viruses, bacteria, fungi, and parasites. 


Antigen 

A substance that causes your immune system to produce antibodies against it – for example, a virus.  


Adjuvant 

A substance that enhances the immune system’s response to the presence of an antigen – for example, aluminium.

Next: Treating like with like - different approaches

Learn more

Page last reviewed: June 2026

Please note: this website is for information only. It is not a replacement for advice from your primary healthcare provider, and it is not legal advice. 


Please consult your healthcare provider before making any changes to medication, diet or lifestyle.


The views of the individuals featured on this website are not necessarily the views of Informing Consent. However, we are united in our efforts to protect children's health.      


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